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It is difficult to situate nurses’ professionalization between a historic model, the recognition of skills, and the assertion of nursing’s autonomy within the health care service. The continuously evolving health demands and requirements of the French population, the constant progress of medicine, and the economic climate put nurses at the heart of tensions between the demand for quality and the continuity of the care, and between professional flexibility and making savings. Care situations, which are becoming increasingly complex, require an almost permanent adaptation of the way in which nurses work. One of the challenges for nursing colleges is to develop a health training model that integrates the development of skills that are relevant to everyday professional situations. Clinical reasoning, a skill at the heart of the nurse’s role, looks at all care situations, contributing to the care adaptation process. Professional teaching develops our understanding of professional situations and provides us with training approaches linked to skills.