TY - BOOK AU - Mazzilli,Sara AU - Chiara,Pensa AU - Costanza,Gaetana AU - Petruzzellis,Alessandra AU - Orlandi,Augusto AU - Bianchi,Luca AU - Campione,Elena AU - Gonzalez,Salvador AU - Pasquali,Paola TI - Overview of germline and somatic genetic alterations in basal and squamous cell carcinoma: a review of the current literature PY - 2021///. N1 - 68 N2 - Non-melanoma skin cancers (NMSCs), including basal and squamous cell carcinomas, represent the most common malignancies among Caucasians. Over two million cases of NMSC occur each year in the US, with a progressive increase in incidence. There are well-known environmental risk factors, such as iatrogenic or ionizing radiation exposure, but the effect of chronic ultraviolet radiation, especially ultraviolet B radiation, is one of the main predisposing factors. Currently, based on our knowledge of the pathophysiology of most NMSCs, we have a better understanding of the associated genetic risk factors. The aim of this study was to evaluate the factors that contribute to the onset of NMSC through a comprehensive literature research UR - https://shs.cairn.info/revue-european-journal-of-dermatology-2021-4-page-447?lang=fr&redirect-ssocas=7080 ER -