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Introduction: Following the fire of the chemical products stored by the Lubrizol (Seveso upper tier) and Normandie Logistique companies on 26 September 2019 in Rouen, a research group bringing together general practitioners (GP), anthropologists and sociologists has undertaken a multidisciplinary qualitative investigation of general practitioners. The initial objective was to study the practice of primary care health professionals following the event. Initiated in February 2020, this survey was strongly transformed by the COVID-19 pandemic. COVID-19 changed the object of this study, imposed a reflection and a link between the two crises, where GPs found themselves once again on the front line. Purpose of research: To analyze the practices of general practitioners in situations of uncertainty in the context of these extraordinary events, namely an industrial fire and a viral pandemic. Methods: Eighteen general practitioners were interviewed between February and July 2019 in semi-structured interviews conducted by a pair of researchers (sociologist and GP). An analysis inspired by the grounded theory was carried out on three levels (individual thematic analysis, paired confrontation, and collective restitution). Conclusion: In the health crisis contexts studied, GPs were confronted with more recurrent complaints while they had relatively little robust knowledge on which to base their responses. Finally, physicians responded to these situations of high uncertainty by drawing in original ways on their personal experiences of these crises.