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Health impact assessment (HIA) is a prospective approach that consists of identifying the potential consequences, both negative and positive, of an intervention on the health of populations with the aim of improving it. Identified as a specific practice in 1999, it rapidly gained in popularity and was progressively deployed on all continents with variations in terms of implementation strategies, area of application, scales of implementation, modes of governance, institutions and actors involved. It is currently booming in France and Quebec, where it is generating real expectations with regard to the issues of health inequalities, democracy and the coordination of sectoral policies. This article, based on our research, provides a brief portrait of HIA in France and introduces questions on the strengths, limitations and added-value of the approach. This special issue sheds light on the practice through applications in different fields and contexts, emphasizes the methodological, political and social issues related to the process as well as the challenges to be met in order to strengthen the potential of HIA to improve decision-making and develop policies and projects that promote health.