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This article presents the measures taken against Avian Influenza in Asia since 1997, and examines the broadening of biosecurity plans to include concerns about biodiversity and development. Showing how Avian Influenza has integrated animal health into global health, it casts a light on the origins of the “One World, One Health” program, which anticipates the emergence of infectious agents at the interface between humans, animals and environment. Looking at techniques of culling, vaccination and surveillance, and how they combine in different Asian countries, it concludes with the implementation of a new normative form : the sentinel of future threats.