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This article assesses the impact of European economic governance on the political and administrative system of Greece in the context of the sovereign debt crisis. It describes the changes in the coordination and administrative system that Greece has put in place according to the requirements of the economic adjustment programmes in order to adapt to the new environment at national and European level. The article assesses how the strict conditions of the Greek membership in the Eurozone have weakened the centrality of the State, the administrative and political sovereignty of Greek governments and their bargaining power in the intergovernmental decision-making bodies governing the Eurozone.