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French Guiana, an overseas French territory in the Amazon, has a unique historical, geographical, demographic, and socio-anthropological context, which produces a completely original psychiatric and addictological clinical environment, requiring an adaptation of national interventions. Our first objective was to conduct a review of the literature and the state of current knowledge in the discipline in French Guyana. Despite a corpus size of 54 titles, these works are often old, little known and difficult to access, poorly valued, disparate and heterogeneous, and opportunistic and disconnected from care, and therefore not very usable. Ultimately, few mental health professionals have conducted research to inform their practice, apart from a few descriptive epidemiological studies on addictive or suicidal risk, on the prison population, or certain indigenous communities. Although descriptive epidemiological and prevalence studies are still lacking and very much necessary, work is also needed on the problems linked to crack consumption, on the phenomena of suicide and suicide contagion, and on psycho-trauma situations (including historical trauma). Similarly, children and young people, people in precarious and/or migrant situations, and indigenous populations should all be given particular attention. The impact of heavy metals and endocrine disruptors on neurodevelopmental disorders in children, and the continuation of cross-disciplinary work with colleagues specializing in infectious diseases and dermatology-venereology should also be considered. Finally, integrative research in the human sciences would be of great value in this multicultural territory where the integration of mediation, the intercultural approach, and the community approach to health are a key paradigm. In a context of transformation into a Centre Hospitalier Régional Universitaire (CHRU) (Regional University Hospital Centre), this “calendar” proposes a roadmap for dynamic and innovative research in psychiatry, addictology, and mental health in the Amazonian context.