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Smyrnium olusatrum L. (Apiaceae) is a plant widely used in traditional Moroccan medicine to alleviate gastric and intestinal pain. However, its pharmacological properties have been relatively little studied. This study aimed to evaluate the antioxidant, anti-inflammatory, and analgesic activities of the methanolic (MeOH) and ethanolic (EtOH) extracts from S. olusatrum, while also assessing their acute toxicity. The acute toxicity study revealed that the LD50 of MeOH and EtOH extracts exceeded 5 g/kg, indicating their low toxicity profile. Phytochemical screening identified the presence of essential compounds such as polyphenols, flavonoids, terpenoids, and alkaloids. Notably, both MeOH and EtOH extracts exhibited potent antioxidant activity. In vitro anti-inflammatory experiments showed a concentration-dependent anti-denaturation effect on BSA and egg albumin. In vivo, the extracts demonstrated strong anti-inflammatory effects by effectively reducing paw edema induced by formaldehyde injection in rats. Furthermore, these studied extracts demonstrated notable analgesic activity, significantly reducing abdominal cramps caused by acetic acid injection. In conclusion, the MeOH and EtOH extracts of S. olusatrum exhibit antioxidant, anti-inflammatory, and analgesic effects, thereby providing scientific support for their traditional medicinal use in Moroccan practices.