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Recently, the issue has been raised about people with chronic diseases returning to or staying in the work place. Interest in this issue is linked to the improvement of medical treatments, to an aging population, and to the increase in number of people suffering from chronic diseases. Research on the relationship to work and its contribution to the invention and maintenance of adequate strategies for coping with disease tend to confuse the terms “work” and “employment,” thereby prioritizing the “containing” instead of the content. On the contrary, the ongoing quantitative research presented here focuses on the concept of “activities” and the interaction processes within the activities system (professional activity, associations’ activity, and activities aiming at controlling chronic disease). This paper identifies resources, experiences, and accumulated skills and their use and adjustment from one area to the other in order to protect and enhance their power for action.