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In line with the economic and geopolitical transformations currently underway, the geography of stocks and flows is undergoing a major recomposition in Europe. In the greater French South-East, a geo-logistical mosaic, the gap between well-serviced and neglected areas has widened during the last 25 years, favouring larger conurbations. In this context, the purpose of this paper is to highlight the broad range of processes contributing to a multi-scale reorganisation of the spatio-logistical system in the area under consideration. These changes need to be taken into account in the political debate on rural and urban planning.