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This article examines the spatial distribution of jobs in the Paris region. Going beyond the standard analysis often centered on economic sectors, it focuses instead on the functions performed by the jobs. We rely on exploratory spatial data analysis (ESDA) and segregation indicators. We bring to light the hyper-monocentric structure of job distribution in the Paris region in 2007 and show its asymmetric and segregated nature. These results call for additional work on the link between (i) spatial differentiation and functional segregation of jobs and (ii) a city’s wealth, productivity and status in the globalised economy. Our findings also raise questions about the potential role of functional hyper-centrality in competition among global metropolises.