Monoclonal immunoglobulin-related nephropathies: From B cell clonal expansion to the renal toxicity of pathological immunoglobulins (notice n° 191213)
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| fixed length control field | 02397cam a2200277 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112044548.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gueye, Serigne |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Monoclonal immunoglobulin-related nephropathies: From B cell clonal expansion to the renal toxicity of pathological immunoglobulins |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 77 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Germinal center regulation pathways are often involved in lymphomagenesis and myelomagenesis. Most lymphomas (and multiple myeloma) derive from post-germinal center B cells that have undergone somatic hypermutation and class switch recombination. B cell clonal expansion is thus sometimes responsible for the presence of a monoclonal component (immunoglobulin) of variable titer that, owing to physicochemical properties, can provoke pathologically defined disease entities. These diseases can affect any functional part of the kidney, by multiple mechanisms, some well known and others not. The presence of renal deposits is influenced by the germinal gene involved, the primary structure of the immunoglobulin, post-translational modifications, and microenvironmental interactions. Pathological immunoglobulins can cause renal toxicity in two ways: (i) excess production (overcoming the catabolism capacity of proximal tubule epithelial cells), with an excess of free light chains within the distal tubules and a subsequent risk of precipitation due to local physicochemical properties; (ii) by structural characteristics that predispose the immunoglobulin to causing renal disease (whatever their titer). The purpose of this article is to review the literature concerning the pathophysiology of renal toxicities of clonal immunoglobulin, from molecular B cell expansion mechanisms to immunoglobulin renal toxicity. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gauthier, Martin |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Benyahia, Rayane |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Trape, Lucas |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dahri, Souad |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kounde, Clément |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Perier, Thomas |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Meklati, Louiza |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Guelib, Imene |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Faye, Maria |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rostaing, Lionel |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Néphrologie & Thérapeutique | Volume 18 | 7 | 2022-07-26 | p. 591-603 | 1769-7255 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-nephrologie-therapeutique-2022-7-page-591?lang=en">https://shs.cairn.info/journal-nephrologie-therapeutique-2022-7-page-591?lang=en</a> |
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